Proximal–distal axis formation in the Drosophila leg
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چکیده
منابع مشابه
Proximodistal axis formation in the Drosophila leg
The developing legs of Drosophila are subdivided into proximal and distal domains by the activity of the homeodomain proteins Homothorax (Hth) and Distal-less (Dll). The expression domains of Dll and Hth are initially reciprocal. Wingless and Dpp define both domains by activating Dll and by repressing Hth in the distal region of the disc. Wg and Dpp do not act through Dll to repress Hth. Hth fu...
متن کاملProximal distal axis formation in the Drosophila leg: distinct functions of Teashirt and Homothorax in the proximal leg
The proximal distal axis of the Drosophila leg is patterned by expression of a number of transcription factors in discrete domains along the axis. The homeodomain protein Homothorax and the zinc-finger protein Teashirt are broadly coexpressed in the presumptive body wall and proximal leg segments. Homothorax has been implicated in forming a boundary between proximal and distal segments of the l...
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Recent advances shed light on the cellular processes that cooperate during oogenesis to produce a fully patterned egg, containing all the maternal information required for embryonic development. Progress has been made in defining the early steps in oocyte specification and it has been shown that progression of oogenesis is controlled by a meiotic checkpoint and requires active maintenance of th...
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Historically, Drosophila has been an extremely popular animal for molecular and developmental biology. There is a substantial accumulation of genetic and cytological knowledge and detailed analysis for the organism. The formation of leg, wing, eye, and other structures from imaginal discs is particularly interesting as these discs undergo dramatic changes in structure. Leg formation in Drosophi...
متن کاملwingless acts through the shaggy/zeste-white 3 kinase to direct dorsal-ventral axis formation in the Drosophila leg.
The secreted glycoproteins encoded by Wnt genes are thought to function as intercellular signaling molecules which convey positional information. Localized expression of Wingless protein is required to specify the fate of ventral cells in the developing Drosophila leg. We report here that Wingless acts through inactivation of the shaggy/zeste white 3 protein kinase to specify ventral cell fate ...
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ژورنال
عنوان ژورنال: Nature
سال: 1997
ISSN: 0028-0836,1476-4687
DOI: 10.1038/40563